Compound Detail
CHEMBL463454
BROUSSONIN B Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL463454 |
| Name | BROUSSONIN B |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CJJJQWAYMRTLJT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
258.3
MW (Da)
3.28
ALogP
3
HBA
2
HBD
49.7
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Pancreatic triacylglycerol lipase CHEMBL1687677 | IC50 | 4.12 | 4.12 | 75400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Pancreatic triacylglycerol lipase | IC50 | = | 75400.0 | nM | 4.12 | Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate... | 22450131 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22450131 | 10.1016/j.bmcl.2012.02.088 | Pancreatic triacylglycerol lipase | 2 |
| 11678652 | 10.1021/np010288l | Aromatase | 1 |
| 22450131 | 10.1016/j.bmcl.2012.02.088 | 3T3-L1 | 1 |
| 30776692 | 10.1016/j.ejmech.2019.01.044 | Proteasome subunit beta type-5 | 1 |
Data from ChEMBL 36 via Core Engine