Assay Detail
Binding
CHEMBL2020730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine erythrocytes AChE by Ellman's method
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.11 | 8.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2019035 | — | — | 1 | 8.30 |
| CHEMBL2019032 | — | — | 1 | 8.30 |
| CHEMBL2019041 | — | — | 1 | 8.19 |
| CHEMBL2019049 | — | — | 1 | 8.00 |
| CHEMBL2019053 | — | — | 1 | 7.76 |
| CHEMBL2019034 | — | — | 1 | 7.46 |
| CHEMBL2019048 | — | — | 1 | 7.42 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL2019038 | — | — | 1 | 7.30 |
| CHEMBL2019030 | — | — | 1 | 7.12 |
| CHEMBL2019043 | — | — | 1 | 7.12 |
| CHEMBL2019051 | — | — | 1 | 7.12 |
| CHEMBL2019044 | — | — | 1 | 7.10 |
| CHEMBL2019050 | — | — | 1 | 7.10 |
| CHEMBL2019040 | — | — | 1 | 7.07 |
| CHEMBL2019054 | — | — | 1 | 7.05 |
| CHEMBL2019037 | — | — | 1 | 7.00 |
| CHEMBL2019027 | — | — | 1 | 7.00 |
| CHEMBL2019029 | — | — | 1 | 6.90 |
| CHEMBL2019039 | — | — | 1 | 6.82 |
| CHEMBL2019031 | — | — | 1 | 6.82 |
| CHEMBL2019028 | — | — | 1 | 6.82 |
| CHEMBL2019042 | — | — | 1 | 6.76 |
| CHEMBL2019046 | — | — | 1 | 6.60 |
| CHEMBL2019052 | — | — | 1 | 6.52 |
| CHEMBL2019045 | — | — | 1 | 6.46 |
| CHEMBL2019047 | — | — | 1 | 6.30 |
| CHEMBL2019036 | — | — | 1 | 6.26 |
| CHEMBL2019033 | — | — | 1 | 6.00 |
| CHEMBL83628 | CHROMOCARB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2019035 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2019032 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2019041 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2019049 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2019053 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL2019034 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2019048 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL95 | TACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2019038 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2019030 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2019043 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2019051 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2019044 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2019050 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2019040 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2019054 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2019037 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2019027 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2019029 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2019039 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2019031 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2019028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2019042 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2019046 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2019052 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2019045 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2019047 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2019036 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2019033 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL83628 | CHROMOCARB | Inhibition | - | % | - |