Assay Detail
Binding
CHEMBL2020772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate and 5 uM ATP by radiometric assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017324 | — | — | 1 | 8.70 |
| CHEMBL2017348 | — | — | 1 | 8.70 |
| CHEMBL2017323 | — | — | 1 | 8.70 |
| CHEMBL2017341 | — | — | 1 | 8.40 |
| CHEMBL2017356 | — | — | 1 | 8.30 |
| CHEMBL2017346 | — | — | 1 | 8.30 |
| CHEMBL2017361 | — | — | 1 | 8.22 |
| CHEMBL2017352 | — | — | 1 | 8.22 |
| CHEMBL2017339 | — | — | 1 | 8.22 |
| CHEMBL2017328 | — | — | 1 | 8.22 |
| CHEMBL2017347 | — | — | 1 | 8.15 |
| CHEMBL2017326 | — | — | 1 | 8.10 |
| CHEMBL2017342 | — | — | 1 | 8.05 |
| CHEMBL2017329 | — | — | 1 | 8.05 |
| CHEMBL2017335 | — | — | 1 | 8.00 |
| CHEMBL2017359 | — | — | 1 | 7.92 |
| CHEMBL2017355 | — | — | 1 | 7.92 |
| CHEMBL2017327 | — | — | 1 | 7.85 |
| CHEMBL2017322 | — | — | 1 | 7.82 |
| CHEMBL2017349 | — | — | 1 | 7.82 |
| CHEMBL2017357 | — | — | 1 | 7.77 |
| CHEMBL2017325 | — | — | 1 | 7.77 |
| CHEMBL2017332 | — | — | 1 | 7.70 |
| CHEMBL2017343 | — | — | 1 | 7.68 |
| CHEMBL2017337 | — | — | 1 | 7.66 |
| CHEMBL2017344 | — | — | 1 | 7.62 |
| CHEMBL2017334 | — | — | 1 | 7.60 |
| CHEMBL2017351 | — | — | 1 | 7.55 |
| CHEMBL2017360 | — | — | 1 | 7.55 |
| CHEMBL2017330 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017324 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017323 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017348 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2017341 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2017356 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017346 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2017361 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017352 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017339 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017328 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2017347 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2017326 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2017342 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017329 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2017335 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017359 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2017355 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2017327 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2017322 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2017349 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2017357 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2017325 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2017332 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2017343 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2017337 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2017344 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2017334 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2017351 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2017360 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2017330 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2017353 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2017331 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2017333 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2017350 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2017336 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2017354 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2017338 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2017345 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2017340 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2017358 | — | IC50 | = | 121.0 | nM | 6.92 |