Assay Detail
Binding
CHEMBL2020792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.15 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017518 | — | — | 1 | 6.60 |
| CHEMBL2017522 | — | — | 1 | 6.45 |
| CHEMBL2017521 | — | — | 1 | 6.31 |
| CHEMBL240954 | — | — | 1 | 6.23 |
| CHEMBL2017519 | — | — | 1 | 6.06 |
| CHEMBL2017517 | — | — | 1 | 5.95 |
| CHEMBL2017523 | — | — | 1 | 5.84 |
| CHEMBL2017520 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017518 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL2017522 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL2017521 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL240954 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL2017519 | — | IC50 | = | 869.0 | nM | 6.06 |
| CHEMBL2017517 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL2017523 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL2017520 | — | IC50 | = | 1920.0 | nM | 5.72 |