Assay Detail
Functional
CHEMBL2021035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunosuppressive activity in anti-CD3/anti-CD8 co-stimulated Balb/c mouse lymph node cells assessed as inhibition of cell proliferation after 72 hrs by ELISA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.16 |
| CHEMBL2016838 | — | — | 1 | 5.23 |
| CHEMBL2016946 | — | — | 1 | 5.21 |
| CHEMBL2016948 | — | — | 1 | 5.20 |
| CHEMBL2016831 | — | — | 1 | 5.07 |
| CHEMBL2016835 | — | — | 1 | 5.04 |
| CHEMBL2016836 | — | — | 1 | 5.02 |
| CHEMBL2016837 | — | — | 1 | 4.97 |
| CHEMBL2016829 | — | — | 1 | 4.96 |
| CHEMBL2016949 | — | — | 1 | 4.96 |
| CHEMBL2016947 | — | — | 1 | 4.95 |
| CHEMBL2016833 | — | — | 1 | 4.95 |
| CHEMBL2016943 | — | — | 1 | 4.95 |
| CHEMBL2016944 | — | — | 1 | 4.94 |
| CHEMBL2016828 | — | — | 1 | 4.94 |
| CHEMBL2016834 | — | — | 1 | 4.93 |
| CHEMBL2016945 | — | — | 1 | 4.93 |
| CHEMBL2016832 | — | — | 1 | 4.91 |
| CHEMBL2016941 | — | — | 1 | 4.88 |
| CHEMBL2016830 | — | — | 1 | 4.86 |
| CHEMBL2016939 | — | — | 1 | 4.83 |
| CHEMBL138314 | 4,4'-DIMETHOXYCHALCONE | — | 1 | 4.63 |
| CHEMBL2016950 | — | — | 1 | 4.60 |
| CHEMBL2016940 | — | — | 1 | - |
| CHEMBL2016942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2016838 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL2016946 | — | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL2016948 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL2016831 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL2016835 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL2016836 | — | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL2016837 | — | IC50 | = | 10640.0 | nM | 4.97 |
| CHEMBL2016829 | — | IC50 | = | 10950.0 | nM | 4.96 |
| CHEMBL2016949 | — | IC50 | = | 10880.0 | nM | 4.96 |
| CHEMBL2016947 | — | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL2016833 | — | IC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL2016943 | — | IC50 | = | 11150.0 | nM | 4.95 |
| CHEMBL2016944 | — | IC50 | = | 11590.0 | nM | 4.94 |
| CHEMBL2016828 | — | IC50 | = | 11480.0 | nM | 4.94 |
| CHEMBL2016834 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL2016945 | — | IC50 | = | 11610.0 | nM | 4.93 |
| CHEMBL2016832 | — | IC50 | = | 12310.0 | nM | 4.91 |
| CHEMBL2016941 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL2016830 | — | IC50 | = | 13930.0 | nM | 4.86 |
| CHEMBL2016939 | — | IC50 | = | 14720.0 | nM | 4.83 |
| CHEMBL138314 | 4,4'-DIMETHOXYCHALCONE | IC50 | = | 23550.0 | nM | 4.63 |
| CHEMBL2016950 | — | IC50 | = | 25080.0 | nM | 4.60 |
| CHEMBL2016940 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL2016942 | — | IC50 | < | 5000.0 | nM | - |