Assay Detail
Functional
CHEMBL2021086
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.50 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555297 | — | — | 1 | 4.96 |
| CHEMBL2017174 | — | — | 1 | 4.89 |
| CHEMBL89700 | METHYLHONOKIOL | — | 1 | 4.75 |
| CHEMBL2017172 | — | — | 1 | 4.62 |
| CHEMBL551195 | — | — | 1 | 4.62 |
| CHEMBL2017171 | — | — | 1 | 4.55 |
| CHEMBL2017169 | — | — | 1 | 4.48 |
| CHEMBL2016584 | — | — | 1 | 4.48 |
| CHEMBL2017176 | — | — | 1 | 4.44 |
| CHEMBL89828 | — | — | 1 | 4.40 |
| CHEMBL2017170 | — | — | 1 | 4.40 |
| CHEMBL2017173 | — | — | 1 | 4.39 |
| CHEMBL2017175 | — | — | 1 | 4.21 |
| CHEMBL2017177 | — | — | 1 | 4.20 |
| CHEMBL2016995 | — | — | 1 | 4.11 |
| CHEMBL2017167 | — | — | 1 | - |
| CHEMBL2017168 | — | — | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL2017166 | — | — | 1 | - |
| CHEMBL2017178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555297 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2017174 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2017172 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL551195 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2017171 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2017169 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2016584 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2017176 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL89828 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2017170 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2017173 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2017175 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL2017177 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL2016995 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL2017167 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017168 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL118 | CELECOXIB | IC50 | = | 12090000.0 | nM | - |
| CHEMBL2017166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017178 | — | IC50 | > | 50000.0 | nM | - |