Assay Detail
ADMET
CHEMBL2021087
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Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by propidium iodide staining based FACS-flow cytometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.41 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555297 | — | — | 1 | 4.89 |
| CHEMBL2017174 | — | — | 1 | 4.82 |
| CHEMBL89700 | METHYLHONOKIOL | — | 1 | 4.57 |
| CHEMBL551195 | — | — | 1 | 4.54 |
| CHEMBL2017171 | — | — | 1 | 4.48 |
| CHEMBL2017169 | — | — | 1 | 4.36 |
| CHEMBL2017173 | — | — | 1 | 4.28 |
| CHEMBL2017177 | — | — | 1 | 4.20 |
| CHEMBL2017172 | — | — | 1 | 4.19 |
| CHEMBL2017175 | — | — | 1 | 4.09 |
| CHEMBL2017170 | — | — | 1 | 4.09 |
| CHEMBL2017166 | — | — | 1 | - |
| CHEMBL2017167 | — | — | 1 | - |
| CHEMBL2017168 | — | — | 1 | - |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL2016995 | — | — | 1 | - |
| CHEMBL89828 | — | — | 1 | - |
| CHEMBL2017176 | — | — | 1 | - |
| CHEMBL2017178 | — | — | 1 | - |
| CHEMBL2016584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555297 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2017174 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL551195 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2017171 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2017169 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2017173 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL2017177 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL2017172 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL2017175 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL2017170 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL2017166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017167 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017168 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL118 | CELECOXIB | IC50 | = | 11130000.0 | nM | - |
| CHEMBL2016995 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89828 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2017176 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2017178 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2016584 | — | IC50 | > | 50000.0 | nM | - |