Assay Detail
Binding
CHEMBL2021209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrate addition measured after 120 mins by spectrophotometry
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL4234) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 7.59 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018254 | — | — | 1 | 9.00 |
| CHEMBL2018141 | — | — | 1 | 8.70 |
| CHEMBL2018139 | — | — | 1 | 8.70 |
| CHEMBL2018249 | — | — | 1 | 8.70 |
| CHEMBL2018142 | — | — | 1 | 8.52 |
| CHEMBL2018131 | — | — | 1 | 8.52 |
| CHEMBL2018250 | — | — | 1 | 8.40 |
| CHEMBL2018242 | — | — | 1 | 8.40 |
| CHEMBL2018238 | — | — | 1 | 8.40 |
| CHEMBL2018251 | — | — | 1 | 8.30 |
| CHEMBL2018253 | — | — | 1 | 8.30 |
| CHEMBL2018135 | — | — | 1 | 8.22 |
| CHEMBL2018140 | — | — | 1 | 8.22 |
| CHEMBL2018136 | — | — | 1 | 8.15 |
| CHEMBL2018138 | — | — | 1 | 7.92 |
| CHEMBL2018252 | — | — | 1 | 7.92 |
| CHEMBL1934492 | — | — | 1 | 7.89 |
| CHEMBL1934493 | — | — | 1 | 7.85 |
| CHEMBL2018223 | — | — | 1 | 7.72 |
| CHEMBL2018247 | — | — | 1 | 7.70 |
| CHEMBL2018241 | — | — | 1 | 7.70 |
| CHEMBL2018240 | — | — | 1 | 7.68 |
| CHEMBL2018232 | — | — | 1 | 7.68 |
| CHEMBL2018237 | — | — | 1 | 7.66 |
| CHEMBL1934491 | — | — | 1 | 7.64 |
| CHEMBL2018225 | — | — | 1 | 7.62 |
| CHEMBL2018230 | — | — | 1 | 7.60 |
| CHEMBL2018260 | — | — | 1 | 7.38 |
| CHEMBL2018228 | — | — | 1 | 7.38 |
| CHEMBL2018226 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018254 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2018141 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018249 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018139 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018142 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2018131 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2018250 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018242 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018238 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018251 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2018253 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2018135 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2018140 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2018136 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2018252 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2018138 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1934492 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1934493 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2018223 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2018247 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2018241 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2018240 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2018232 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2018237 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1934491 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2018225 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2018230 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2018260 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2018228 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2018226 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2018231 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2018137 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2018227 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2018239 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2018236 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2018132 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2018243 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018134 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018245 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018233 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018259 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2018128 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2018246 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL2018130 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2018248 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2018229 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2018129 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2018127 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2018234 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2018133 | — | IC50 | - | — | - |