Assay Detail
Functional
CHEMBL2024707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anesthetic effect on Xenopus laevis tadpole assessed as loss of swimming reflex
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Tissue | Tadpole |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.65 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021957 | — | — | 1 | 6.57 |
| CHEMBL3138531 | — | — | 1 | 6.26 |
| CHEMBL2021955 | — | — | 1 | 6.06 |
| CHEMBL3138444 | — | — | 1 | 5.57 |
| CHEMBL429756 | — | — | 1 | 5.56 |
| CHEMBL3138534 | — | — | 1 | 5.56 |
| CHEMBL3138532 | — | — | 1 | 5.53 |
| CHEMBL3138533 | — | — | 1 | 5.46 |
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 5.26 |
| CHEMBL3138446 | — | — | 1 | 5.26 |
| CHEMBL2021961 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021957 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3138531 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2021955 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3138444 | — | EC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL429756 | — | EC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3138534 | — | EC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL3138532 | — | EC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL3138533 | — | EC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL207538 | BREXANOLONE | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3138446 | — | EC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL2021961 | — | EC50 | = | 7940.0 | nM | 5.10 |