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Assay Detail

CHEMBL2024728

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 1 hr by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.
Congreve M, Andrews SP, Doré AS, Hollenstein K, Hurrell E, Langmead CJ, Mason JS, Ng IW, Tehan B, Zhukov A, Weir M, Marshall FH.
J Med Chem (2012) 55 : 1898 -1903
PubMed 22220592 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.26 9.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2024114 1 9.79
CHEMBL2021950 1 7.78
CHEMBL2024119 1 7.50
CHEMBL2024112 1 7.36
CHEMBL2024111 1 7.25
CHEMBL2024115 1 7.07
CHEMBL2024118 1 6.96
CHEMBL2024120 1 6.93
CHEMBL2024117 1 6.77
CHEMBL2024113 1 6.71
CHEMBL1370747 1 6.56
CHEMBL2024116 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2024114 Ki = 0.1622 nM 9.79
CHEMBL2021950 Ki = 16.6 nM 7.78
CHEMBL2024119 Ki = 31.62 nM 7.50
CHEMBL2024112 Ki = 43.65 nM 7.36
CHEMBL2024111 Ki = 56.23 nM 7.25
CHEMBL2024115 Ki = 85.11 nM 7.07
CHEMBL2024118 Ki = 109.65 nM 6.96
CHEMBL2024120 Ki = 117.49 nM 6.93
CHEMBL2024117 Ki = 169.82 nM 6.77
CHEMBL2024113 Ki = 194.98 nM 6.71
CHEMBL1370747 Ki = 275.42 nM 6.56
CHEMBL2024116 Ki = 398.11 nM 6.40