Assay Detail
Binding
CHEMBL2024732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to adenosine A2A receptor by surface plasmon resonance
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.96 | 9.80 |
| pKd | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021950 | — | — | 1 | 9.80 |
| CHEMBL2024114 | — | — | 1 | 9.60 |
| CHEMBL2024115 | — | — | 1 | 8.90 |
| CHEMBL2024118 | — | — | 1 | 8.50 |
| CHEMBL2024119 | — | — | 1 | 8.50 |
| CHEMBL2024116 | — | — | 1 | 8.00 |
| CHEMBL2024117 | — | — | 1 | 8.00 |
| CHEMBL2024120 | — | — | 1 | 7.60 |
| CHEMBL2024112 | — | — | 1 | 7.30 |
| CHEMBL2024111 | — | — | 1 | 6.40 |
| CHEMBL1370747 | — | — | 1 | 5.00 |
| CHEMBL2024113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021950 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL2024114 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL2024115 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL2024118 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL2024119 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL2024116 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2024117 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2024120 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL2024112 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL2024111 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL1370747 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL2024113 | — | pKd | - | — | - |