Assay Detail
Binding
CHEMBL2024840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IRAK4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.20 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1739550 | — | — | 1 | 7.25 |
| CHEMBL2022369 | — | — | 1 | 6.06 |
| CHEMBL2022379 | — | — | 1 | 5.94 |
| CHEMBL2022711 | — | — | 1 | 5.91 |
| CHEMBL2022373 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1739550 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2022369 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL2022379 | — | IC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL2022711 | — | IC50 | = | 1219.0 | nM | 5.91 |
| CHEMBL2022373 | — | IC50 | = | 1423.0 | nM | 5.85 |