Interleukin-1 receptor-associated kinase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Interleukin-1 receptor-associated kinase 4 shows clinical signal disease relevance led by COVID-19. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9NWZ3. Start with COVID-19, then reuse UniProt Q9NWZ3 as the stable protein anchor across project notes and exports.
Start with COVID-19, then reuse UniProt Q9NWZ3 as the stable protein anchor across project notes and exports.
Interleukin-1 receptor-associated kinase 4 shows clinical signal disease relevance led by COVID-19. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include ZIMLOVISERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyInterleukin-1 receptor-associated kinase 4
Review this target as Interleukin-1 receptor-associated kinase 4, mapped to UniProt Q9NWZ3. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Interleukin-1 receptor-associated kinase 4 as ChEMBL target CHEMBL3778, mapped to UniProt Q9NWZ3. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Interleukin-1 receptor-associated kinase 4 is the right protein anchor across sources, using UniProt Q9NWZ3 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why COVID-19 is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Interleukin-1 receptor-associated kinase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NWZ3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-1 receptor-associated kinase 4 |
| UniProt Accession | Q9NWZ3 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Interleukin-1 receptor-associated kinase 4
Review this target as Interleukin-1 receptor-associated kinase 4, mapped to UniProt Q9NWZ3. Sequence length is 460 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Interleukin-1 receptor-associated kinase 4 shows clinical signal disease relevance led by COVID-19. 4 more disease programs remain visible in the same review block.
Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include ZIMLOVISERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4443947 | 10.66 | IC50 | 0.022 | Preclinical |
| CHEMBL4556091 | 10.59 | IC50 | 0.026 | Preclinical |
| CHEMBL4566431 | 10.11 | IC50 | 0.078 | Preclinical |
| CHEMBL4545898 | 10.09 | IC50 | 0.081 | Preclinical |
| CHEMBL5190644 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4081711 | 10.0 | IC50 | 0.1 | Clinical |
| CHEMBL4520946 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4448950 | 10.0 | IC50 | 0.099 | Preclinical |
| CHEMBL4445098 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4066705 | 10.0 | IC50 | 0.1 | Preclinical |