Compound Detail
CHEMBL4520946
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Basic Information
| ChEMBL ID | CHEMBL4520946 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVYXXOWVKHZMEJ-KHIZAZIESA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
360.4
MW (Da)
2.19
ALogP
4
HBA
2
HBD
90.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 CHEMBL3778 | IC50 | 10.0 | 9.6 | 0.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 0.1 | nM | 10.0 | IRAK4 Enzymatic DELFIA Assay, Protocol B: This is an in vitro assay to measure I... | - |
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 0.2 | nM | 9.7 | Inhibition of IRAK4 (unknown origin) | 30530193 |
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 0.8 | nM | 9.1 | IRAK4 Enzymatic DELFIA Assay, Protocol A: This is an in vitro assay to measure I... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30530193 | 10.1016/j.ejmech.2018.11.072 | Interleukin-1 receptor-associated kinase 4 | 1 |
Data from ChEMBL 36 via Core Engine