Assay Detail
Binding
CHEMBL4331758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IRAK4 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.30 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4520946 | — | — | 1 | 9.70 |
| CHEMBL3361255 | — | — | 1 | 8.89 |
| CHEMBL3361254 | — | — | 1 | 8.12 |
| CHEMBL4579427 | — | — | 1 | 7.48 |
| CHEMBL4064608 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4520946 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3361255 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3361254 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4579427 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4064608 | — | IC50 | = | 51.0 | nM | 7.29 |