Assay Detail
Functional
CHEMBL2025481
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Antiviral activity against CCR5-tropic HIV1 NL-AD87 infected in HEK293T cells assessed as inhibition of viral replication after 4 days by beta-galactosidase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.00 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023370 | GNIDICIN | — | 1 | 7.75 |
| CHEMBL2023369 | DAPHNETOXIN | — | 1 | 7.57 |
| CHEMBL1159653 | GNIDITRIN | — | 1 | 6.88 |
| CHEMBL447856 | EXCOECARIA TOXIN | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023370 | GNIDICIN | EC50 | = | 17.6 | nM | 7.75 |
| CHEMBL2023369 | DAPHNETOXIN | EC50 | = | 26.7 | nM | 7.57 |
| CHEMBL1159653 | GNIDITRIN | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL447856 | EXCOECARIA TOXIN | EC50 | = | 1567.0 | nM | 5.80 |