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Assay Detail

CHEMBL2025543

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.
Dinio T, Gorka AP, McGinniss A, Roepe PD, Morgan JB.
Bioorg Med Chem (2012) 20 : 3292 -3297
PubMed 22512909 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.55 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL588619 CINCHONINE -1.0 1 7.09
CHEMBL1294 QUINIDINE 4.0 1 7.05
CHEMBL2024445 1 6.84
CHEMBL2024434 1 6.75
CHEMBL2024441 1 6.74
CHEMBL2023834 1 6.74
CHEMBL2024435 1 6.70
CHEMBL2024438 1 6.70
CHEMBL2024439 1 6.69
CHEMBL533841 CINCHONIDINE -1.0 1 6.68
CHEMBL2024436 1 6.65
CHEMBL2024442 1 6.61
CHEMBL2024443 1 6.58
CHEMBL2023835 1 6.50
CHEMBL170 QUININE 4.0 1 6.50
CHEMBL2024429 1 6.31
CHEMBL2023837 1 6.13
CHEMBL2024437 1 6.03
CHEMBL2024444 1 6.01
CHEMBL2024440 1 5.63
CHEMBL2024433 1 -
CHEMBL2024432 1 -
CHEMBL2024431 1 -
CHEMBL2024430 1 -
CHEMBL2024428 1 -
CHEMBL2023836 1 -
CHEMBL2023833 1 -
CHEMBL2023832 1 -
CHEMBL2023831 1 -
CHEMBL2023830 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL588619 CINCHONINE IC50 = 82.0 nM 7.09
CHEMBL1294 QUINIDINE IC50 = 90.0 nM 7.05
CHEMBL2024445 IC50 = 146.0 nM 6.84
CHEMBL2024434 IC50 = 176.0 nM 6.75
CHEMBL2024441 IC50 = 182.0 nM 6.74
CHEMBL2023834 IC50 = 184.0 nM 6.74
CHEMBL2024435 IC50 = 198.0 nM 6.70
CHEMBL2024438 IC50 = 202.0 nM 6.70
CHEMBL2024439 IC50 = 203.0 nM 6.69
CHEMBL533841 CINCHONIDINE IC50 = 207.0 nM 6.68
CHEMBL2024436 IC50 = 223.0 nM 6.65
CHEMBL2024442 IC50 = 243.0 nM 6.61
CHEMBL2024443 IC50 = 263.0 nM 6.58
CHEMBL2023835 IC50 = 318.0 nM 6.50
CHEMBL170 QUININE IC50 = 320.0 nM 6.50
CHEMBL2024429 IC50 = 485.0 nM 6.31
CHEMBL2023837 IC50 = 733.0 nM 6.13
CHEMBL2024437 IC50 = 928.0 nM 6.03
CHEMBL2024444 IC50 = 983.0 nM 6.01
CHEMBL2024440 IC50 = 2350.0 nM 5.63
CHEMBL2024433 IC50 > 500.0 nM -
CHEMBL2024432 IC50 > 500.0 nM -
CHEMBL2024431 IC50 > 500.0 nM -
CHEMBL2024430 IC50 > 500.0 nM -
CHEMBL2024428 IC50 > 500.0 nM -
CHEMBL2023836 IC50 > 500.0 nM -
CHEMBL2023833 IC50 > 500.0 nM -
CHEMBL2023832 IC50 > 1500.0 nM -
CHEMBL2023831 IC50 > 500.0 nM -
CHEMBL2023830 IC50 > 500.0 nM -
CHEMBL2023829 IC50 > 500.0 nM -