Assay Detail
Binding
CHEMBL2025841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescein-labeled phosphotyrosine-peptide derived from the interleukin-6 receptor subunit gp130 from the STAT3 after 15 mins by fluorescent polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.07 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023985 | — | — | 1 | 5.55 |
| CHEMBL1829870 | — | — | 1 | 5.21 |
| CHEMBL1829862 | — | — | 1 | 5.10 |
| CHEMBL2023989 | — | — | 1 | 5.10 |
| CHEMBL2023986 | — | — | 1 | 5.08 |
| CHEMBL2023987 | — | — | 1 | 5.08 |
| CHEMBL1829874 | — | — | 1 | 4.96 |
| CHEMBL1829786 | — | — | 1 | 4.81 |
| CHEMBL2023988 | — | — | 1 | 4.75 |
| CHEMBL2024086 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023985 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1829870 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL1829862 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2023989 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL2023986 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL2023987 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL1829874 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1829786 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL2023988 | — | Ki | = | 17600.0 | nM | 4.75 |
| CHEMBL2024086 | — | Ki | > | 25000.0 | nM | - |