Assay Detail
Binding
CHEMBL2025934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA1 pre-incubated for 15 mins by stopped-flow CO2 hydration method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.71 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023727 | MORPHOLINECARBAMODITHIOATE SODIUM SALT | — | 1 | 9.06 |
| CHEMBL2021946 | — | — | 1 | 9.02 |
| CHEMBL2023719 | DIISOBUTYLCARBODITHIOIC ACID SODIUM SALT | — | 1 | 9.01 |
| CHEMBL2023730 | — | — | 1 | 8.60 |
| CHEMBL2023169 | — | — | 1 | 8.46 |
| CHEMBL2023171 | — | — | 1 | 8.41 |
| CHEMBL2023168 | SODIUM BENZYLCARBAMODITHIOATE | — | 1 | 8.39 |
| CHEMBL2023170 | — | — | 1 | 8.35 |
| CHEMBL2023163 | POTASSIUM MORPHOLINOCARBAMODITHIOATE | — | 1 | 8.32 |
| CHEMBL2023162 | TRIETHYLAMMONIUM PHENYLCARBAMODITHIOATE | — | 1 | 8.32 |
| CHEMBL2023718 | — | — | 1 | 8.07 |
| CHEMBL2023724 | — | — | 1 | 8.04 |
| CHEMBL2023728 | PIPERAZINECARBAMODITHIOATE DISODIUM SALT | — | 1 | 7.90 |
| CHEMBL2023172 | — | — | 1 | 7.88 |
| CHEMBL2023165 | — | — | 1 | 7.68 |
| CHEMBL2023166 | — | — | 1 | 7.50 |
| CHEMBL2023167 | — | — | 1 | 7.50 |
| CHEMBL2023164 | — | — | 1 | 7.47 |
| CHEMBL2023725 | SODIUM METHYL(PHENYL)CARBAMODITHIOATE | — | 1 | 7.40 |
| CHEMBL2023721 | DIBUTYLCARBAMODITHIOATE SODIUM SALT | — | 1 | 7.37 |
| CHEMBL2023722 | DIHEXYLCARBAMODITHIOATE SODIUM SALT | — | 1 | 7.32 |
| CHEMBL2023729 | — | — | 1 | 7.32 |
| CHEMBL2023726 | SODIUM BENZYL(METHYL)CARBAMODITHIOATE | — | 1 | 7.16 |
| CHEMBL2023723 | ETHYLBUTYLCARBAMODITHIOATE SODIUM SALT | — | 1 | 6.80 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL569460 | SODIUM DIMETHYLCARBAMODITHIOATE | — | 1 | 6.16 |
| CHEMBL107217 | DITIOCARB SODIUM | 2.0 | 1 | 6.10 |
| CHEMBL2023720 | DIPROPYLCARBAMODITHIOATE SODIUM SALT | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023727 | MORPHOLINECARBAMODITHIOATE SODIUM SALT | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL2021946 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL2023719 | DIISOBUTYLCARBODITHIOIC ACID SODIUM SALT | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL2023730 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2023169 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2023171 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2023168 | SODIUM BENZYLCARBAMODITHIOATE | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL2023170 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2023163 | POTASSIUM MORPHOLINOCARBAMODITHIOATE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2023162 | TRIETHYLAMMONIUM PHENYLCARBAMODITHIOATE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2023718 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL2023724 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL2023728 | PIPERAZINECARBAMODITHIOATE DISODIUM SALT | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL2023172 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL2023165 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL2023166 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL2023167 | — | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL2023164 | — | Ki | = | 33.5 | nM | 7.47 |
| CHEMBL2023725 | SODIUM METHYL(PHENYL)CARBAMODITHIOATE | Ki | = | 39.6 | nM | 7.40 |
| CHEMBL2023721 | DIBUTYLCARBAMODITHIOATE SODIUM SALT | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL2023722 | DIHEXYLCARBAMODITHIOATE SODIUM SALT | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL2023729 | — | Ki | = | 48.4 | nM | 7.32 |
| CHEMBL2023726 | SODIUM BENZYL(METHYL)CARBAMODITHIOATE | Ki | = | 69.9 | nM | 7.16 |
| CHEMBL2023723 | ETHYLBUTYLCARBAMODITHIOATE SODIUM SALT | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL569460 | SODIUM DIMETHYLCARBAMODITHIOATE | Ki | = | 699.0 | nM | 6.16 |
| CHEMBL107217 | DITIOCARB SODIUM | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL2023720 | DIPROPYLCARBAMODITHIOATE SODIUM SALT | Ki | = | 1838.0 | nM | 5.74 |