Assay Detail
Functional
CHEMBL2025982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vesicular stomatitis virus infected in HeLa cells assessed as inhibition of virus-induced cytopathogenicity after 4 days
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vesicular stomatitis virus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Vesicular stomatitis virus (CHEMBL613739) ↗| Type | ORGANISM |
| Organism | Vesicular stomatitis virus |
Publication
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.66 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494759 | (S)-DHPA | — | 1 | 4.66 |
| CHEMBL2023440 | — | — | 1 | - |
| CHEMBL2023441 | — | — | 1 | - |
| CHEMBL2023442 | — | — | 1 | - |
| CHEMBL2023604 | — | — | 1 | - |
| CHEMBL2023605 | — | — | 1 | - |
| CHEMBL2023608 | — | — | 1 | - |
| CHEMBL2023610 | — | — | 1 | - |
| CHEMBL2023606 | — | — | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494759 | (S)-DHPA | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2023440 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL2023441 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2023442 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2023604 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2023605 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2023608 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2023610 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2023606 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL1643 | RIBAVIRIN | EC50 | > | 250000.0 | nM | - |