Assay Detail
Binding
CHEMBL2026544
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Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.29 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024544 | — | — | 1 | 6.70 |
| CHEMBL2024561 | — | — | 1 | 6.21 |
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024544 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL2024561 | — | Kd | = | 620.0 | nM | 6.21 |
| CHEMBL1096380 | PLINABULIN | Kd | = | 1060.0 | nM | 5.97 |