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Assay Detail

CHEMBL2027147

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.
Pan L, Yong Y, Deng Y, Lantvit DD, Ninh TN, Chai H, Carcache de Blanco EJ, Soejarto DD, Swanson SM, Kinghorn AD.
J Nat Prod (2012) 75 : 444 -452
PubMed 22239601 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.48 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 8.22
CHEMBL2022241 1 7.41
CHEMBL493646 CUCURBITACIN D 1 6.92
CHEMBL387737 CUCURBITACIN I 1 6.72
CHEMBL2023378 ELAEOCARPUCIN C 1 6.39
CHEMBL447610 1 6.27
CHEMBL2022240 ELAEOCARPUCIN H 1 5.57
CHEMBL2023382 ELAEOCARPUCIN G 1 5.54
CHEMBL2023379 ELAEOCARPUCIN D 1 5.25
CHEMBL2023376 ELAEOCARPUCIN A 1 -
CHEMBL2022242 1 -
CHEMBL2023381 ELAEOCARPUCIN F 1 -
CHEMBL2023380 ELAEOCARPUCIN E 1 -
CHEMBL2023377 ELAEOCARPUCIN B 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 6.0 nM 8.22
CHEMBL2022241 IC50 = 39.0 nM 7.41
CHEMBL493646 CUCURBITACIN D IC50 = 120.0 nM 6.92
CHEMBL387737 CUCURBITACIN I IC50 = 190.0 nM 6.72
CHEMBL2023378 ELAEOCARPUCIN C IC50 = 410.0 nM 6.39
CHEMBL447610 IC50 = 540.0 nM 6.27
CHEMBL2022240 ELAEOCARPUCIN H IC50 = 2700.0 nM 5.57
CHEMBL2023382 ELAEOCARPUCIN G IC50 = 2900.0 nM 5.54
CHEMBL2023379 ELAEOCARPUCIN D IC50 = 5600.0 nM 5.25
CHEMBL2023376 ELAEOCARPUCIN A IC50 > 10000.0 nM -
CHEMBL2022242 IC50 > 10000.0 nM -
CHEMBL2023381 ELAEOCARPUCIN F IC50 > 10000.0 nM -
CHEMBL2023380 ELAEOCARPUCIN E IC50 > 10000.0 nM -
CHEMBL2023377 ELAEOCARPUCIN B IC50 > 10000.0 nM -