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Compound Detail

CHEMBL2022240

ELAEOCARPUCIN H
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CC(C)=C[C@H]1C[C@](C)(O)[C@H]2[C@@H](C[C@@]3(C)[C@@H]4C(=O)C=C5[C@@H](CC[C@H](O)C5(C)C)[C@]4(C)C(=O)C[C@]23C)O1

Basic Information

ChEMBL ID CHEMBL2022240
Name ELAEOCARPUCIN H
Phase Preclinical
Structure Type MOL
InChI Key KYAJJIYYRHRDHS-AOPDKZAKSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

484.7
MW (Da)
4.80
ALogP
5
HBA
2
HBD
83.8
PSA (Ų)
0.52
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H44O5
MW 484.68
Aromatic Rings 0
Heavy Atoms 35
NP-Likeness 3.30

Activity Summary

IC50 1 meas. best 5.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HT-29
CHEMBL384
IC50 5.57 5.57 2700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
HT-29 IC50 = 2700.0 nM 5.57 Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay 22239601

Literature References

PubMed DOI Target Context # Activities
22239601 10.1021/np200879p HT-29 1

Data from ChEMBL 36 via Core Engine