Assay Detail
Binding
CHEMBL2027168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.72 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 9.00 |
| CHEMBL2023587 | — | — | 1 | 6.14 |
| CHEMBL2023585 | — | — | 1 | 6.07 |
| CHEMBL2023584 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2023587 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2023585 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2023584 | — | EC50 | = | 2200.0 | nM | 5.66 |