Assay Detail
Binding
CHEMBL2027232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL kinase
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.69 | 8.96 |
| INH | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.96 |
| CHEMBL254702 | — | — | 1 | 8.19 |
| CHEMBL2023349 | R428 | — | 1 | 7.85 |
| CHEMBL2023351 | — | — | 1 | 7.80 |
| CHEMBL2023350 | — | — | 1 | 7.52 |
| CHEMBL2023352 | — | — | 1 | 7.00 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.52 |
| CHEMBL2023353 | — | — | 1 | - |
| CHEMBL2023354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460702 | BMS-777607 | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL254702 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL2023349 | R428 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2023351 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2023350 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2023352 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2023353 | — | INH | = | 33.0 | uM | - |
| CHEMBL2023354 | — | INH | = | 47.0 | uM | - |