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Assay Detail

CHEMBL2028074

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro).
ChEMBL ↗
400
Total Activities
400
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851) ↗
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Malaria Box
Simon Macdonald, Paul Willis, Paul Kowalczyk, Thomas Spangenberg, Jeremy Burrows and Tim Wells. Medicines for Malaria Venture (MMV), PO Box 1826, 20, rte de Pré-Bois, 1215 Geneva 15, Switzerland and SCYNEXIS Inc. P.O. Box 12878 Research Triangle Park, North Carolina 27709-2878 USA

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 400 5.25 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL596852 — — 1 6.75
CHEMBL530531 — — 1 6.73
CHEMBL588501 — — 1 6.66
CHEMBL1437888 — — 1 6.59
CHEMBL602312 — — 1 6.57
CHEMBL2028043 — — 1 6.55
CHEMBL582666 — — 1 6.48
CHEMBL2028064 — — 1 6.32
CHEMBL589733 — — 1 6.18
CHEMBL527730 — — 1 6.15
CHEMBL546531 — — 1 6.09
CHEMBL600374 — — 1 6.07
CHEMBL533399 — — 1 6.07
CHEMBL588481 — — 1 6.06
CHEMBL605751 — — 1 6.06
CHEMBL537087 — — 1 6.04
CHEMBL602234 — — 1 6.04
CHEMBL591637 — — 1 6.03
CHEMBL584235 — — 1 6.03
CHEMBL494669 — — 1 6.01
CHEMBL591183 — — 1 6.00
CHEMBL589946 — — 1 6.00
CHEMBL586031 — — 1 6.00
CHEMBL590933 — — 1 5.99
CHEMBL592123 — — 1 5.99
CHEMBL590212 — — 1 5.99
CHEMBL106525 — — 1 5.99
CHEMBL584015 — — 1 5.99
CHEMBL534319 — — 1 5.99
CHEMBL586033 — — 1 5.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL596852 — IC50 = 179.46 nM 6.75
CHEMBL530531 — IC50 = 185.14 nM 6.73
CHEMBL588501 — IC50 = 219.88 nM 6.66
CHEMBL1437888 — IC50 = 259.05 nM 6.59
CHEMBL602312 — IC50 = 270.98 nM 6.57
CHEMBL2028043 — IC50 = 279.86 nM 6.55
CHEMBL582666 — IC50 = 331.81 nM 6.48
CHEMBL2028064 — IC50 = 481.11 nM 6.32
CHEMBL589733 — IC50 = 656.76 nM 6.18
CHEMBL527730 — IC50 = 711.01 nM 6.15
CHEMBL546531 — IC50 = 804.72 nM 6.09
CHEMBL533399 — IC50 = 860.12 nM 6.07
CHEMBL600374 — IC50 = 850.94 nM 6.07
CHEMBL588481 — IC50 = 876.68 nM 6.06
CHEMBL605751 — IC50 = 879.54 nM 6.06
CHEMBL602234 — IC50 = 922.56 nM 6.04
CHEMBL537087 — IC50 = 907.81 nM 6.04
CHEMBL591637 — IC50 = 930.81 nM 6.03
CHEMBL584235 — IC50 = 930.81 nM 6.03
CHEMBL494669 — IC50 = 969.66 nM 6.01
CHEMBL586031 — IC50 = 1007.03 nM 6.00
CHEMBL591183 — IC50 = 1000.0 nM 6.00
CHEMBL589946 — IC50 = 1000.0 nM 6.00
CHEMBL586033 — IC50 = 1014.25 nM 5.99
CHEMBL590212 — IC50 = 1021.67 nM 5.99
CHEMBL106525 — IC50 = 1029.3 nM 5.99
CHEMBL592123 — IC50 = 1021.67 nM 5.99
CHEMBL534319 — IC50 = 1021.67 nM 5.99
CHEMBL590933 — IC50 = 1014.25 nM 5.99
CHEMBL584015 — IC50 = 1021.67 nM 5.99
CHEMBL591362 — IC50 = 1037.16 nM 5.98
CHEMBL585622 — IC50 = 1037.16 nM 5.98
CHEMBL600235 — IC50 = 1152.54 nM 5.94
CHEMBL547266 — IC50 = 1202.32 nM 5.92
CHEMBL547825 — IC50 = 1309.38 nM 5.88
CHEMBL534283 — IC50 = 1332.18 nM 5.88
CHEMBL588855 — IC50 = 1406.92 nM 5.85
CHEMBL548209 — IC50 = 1892.12 nM 5.72
CHEMBL582072 — IC50 = 1937.97 nM 5.71
CHEMBL10835 — IC50 = 2499.13 nM 5.60
CHEMBL525106 — IC50 = 2767.82 nM 5.56
CHEMBL580516 — IC50 = 2782.13 nM 5.56
CHEMBL580140 — IC50 = 2728.82 nM 5.56
CHEMBL581225 — IC50 = 2843.1 nM 5.55
CHEMBL545880 — IC50 = 2890.36 nM 5.54
CHEMBL578294 — IC50 = 2946.14 nM 5.53
CHEMBL584240 — IC50 = 2999.28 nM 5.52
CHEMBL535730 — IC50 = 3054.87 nM 5.51
CHEMBL548901 — IC50 = 3088.41 nM 5.51
CHEMBL584841 — IC50 = 3272.8 nM 5.49