Assay Detail
Functional
CHEMBL2032597
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Cytotoxicity against human K562 cells after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.49 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2031705 | — | — | 1 | 4.78 |
| CHEMBL36668 | TRYPROSTATIN B | — | 1 | 4.68 |
| CHEMBL2031707 | — | — | 1 | 4.53 |
| CHEMBL2031706 | — | — | 1 | 4.52 |
| CHEMBL288188 | — | — | 1 | 4.51 |
| CHEMBL2031708 | — | — | 1 | 4.50 |
| CHEMBL2031714 | — | — | 1 | 4.49 |
| CHEMBL2031712 | — | — | 1 | 4.46 |
| CHEMBL2031711 | — | — | 1 | 4.46 |
| CHEMBL38396 | — | — | 1 | 4.46 |
| CHEMBL2031713 | — | — | 1 | 4.45 |
| CHEMBL2031710 | — | — | 1 | 4.45 |
| CHEMBL35821 | — | — | 1 | 4.39 |
| CHEMBL2031709 | — | — | 1 | 4.15 |
| CHEMBL2031510 | — | — | 1 | - |
| CHEMBL2031511 | — | — | 1 | - |
| CHEMBL2031512 | — | — | 1 | - |
| CHEMBL2031513 | — | — | 1 | - |
| CHEMBL2031514 | — | — | 1 | - |
| CHEMBL2031704 | — | — | 1 | - |
| CHEMBL2031508 | — | — | 1 | - |
| CHEMBL190059 | — | — | 1 | - |
| CHEMBL191476 | — | — | 1 | - |
| CHEMBL2031509 | — | — | 1 | - |
| CHEMBL365348 | — | — | 1 | - |
| CHEMBL226544 | — | — | 1 | - |
| CHEMBL563557 | BREVIANAMIDE F | — | 1 | - |
| CHEMBL191011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2031705 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL36668 | TRYPROSTATIN B | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL2031707 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL2031706 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL288188 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL2031708 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL2031714 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL2031712 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL2031711 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL38396 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL2031713 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL2031710 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL35821 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL2031709 | — | IC50 | = | 70400.0 | nM | 4.15 |
| CHEMBL2031510 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031511 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031512 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031514 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031508 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL190059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2031509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL365348 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL226544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563557 | BREVIANAMIDE F | IC50 | > | 100000.0 | nM | - |
| CHEMBL191011 | — | IC50 | > | 100000.0 | nM | - |