Assay Detail
Functional
CHEMBL2033198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity in human HuTu 80 cells assessed as cell viability after 72 hrs by MTT assay
13
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuTu80 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.26 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.86 |
| CHEMBL2032319 | — | — | 3 | 8.52 |
| CHEMBL2032213 | — | — | 3 | 8.10 |
| CHEMBL2032214 | — | — | 1 | 7.54 |
| CHEMBL2032323 | — | — | 1 | 7.00 |
| CHEMBL2032212 | — | — | 1 | 6.90 |
| CHEMBL2032321 | — | — | 1 | 6.39 |
| CHEMBL2032322 | — | — | 1 | 6.28 |
| CHEMBL2032320 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL2032319 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL2032213 | — | IC50 | = | 8.02 | nM | 8.10 |
| CHEMBL2032213 | — | IC50 | = | 9.05 | nM | 8.04 |
| CHEMBL2032319 | — | IC50 | = | 13.36 | nM | 7.87 |
| CHEMBL2032214 | — | IC50 | = | 28.79 | nM | 7.54 |
| CHEMBL2032213 | — | IC50 | = | 83.55 | nM | 7.08 |
| CHEMBL2032323 | — | IC50 | = | 101.17 | nM | 7.00 |
| CHEMBL2032212 | — | IC50 | = | 124.6 | nM | 6.90 |
| CHEMBL2032321 | — | IC50 | = | 405.5 | nM | 6.39 |
| CHEMBL2032322 | — | IC50 | = | 528.55 | nM | 6.28 |
| CHEMBL2032319 | — | IC50 | = | 589.9 | nM | 6.23 |
| CHEMBL2032320 | — | IC50 | = | 2549.0 | nM | 5.59 |