Assay Detail
Functional
CHEMBL2033204
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Antiproliferative activity in human SK-N-BE cells assessed as cell viability after 72 hrs by MTT assay
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-BE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.82 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.24 |
| CHEMBL2032213 | — | — | 2 | 8.95 |
| CHEMBL2032319 | — | — | 2 | 8.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2032213 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL2032319 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL2032213 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL2032319 | — | IC50 | = | 4.2 | nM | 8.38 |