Assay Detail
Binding
CHEMBL2033207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometry
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2032213 | — | — | 2 | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.88 |
| CHEMBL2032319 | — | — | 2 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2032213 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2032319 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL2032213 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2032319 | — | IC50 | = | 3800.0 | nM | 5.42 |