Assay Detail
Binding
CHEMBL2033274
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Inhibition of CETP in human plasma assessed as transfer of fluorescently labelled cholesteryl ester to VLDL by fluorimetry
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.03 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2032415 | — | — | 1 | 7.89 |
| CHEMBL2029489 | — | — | 1 | 7.82 |
| CHEMBL2029482 | — | — | 1 | 7.82 |
| CHEMBL2029483 | — | — | 1 | 7.80 |
| CHEMBL2029481 | — | — | 1 | 7.64 |
| CHEMBL2032417 | — | — | 1 | 7.62 |
| CHEMBL2032416 | — | — | 1 | 7.58 |
| CHEMBL2029484 | — | — | 1 | 7.54 |
| CHEMBL2032422 | — | — | 1 | 7.44 |
| CHEMBL2032424 | — | — | 1 | 7.43 |
| CHEMBL479527 | TORCETRAPIB | 3.0 | 1 | 7.41 |
| CHEMBL2029379 | — | — | 1 | 7.40 |
| CHEMBL2032421 | — | — | 1 | 7.38 |
| CHEMBL2029486 | — | — | 1 | 7.36 |
| CHEMBL2032425 | — | — | 1 | 7.33 |
| CHEMBL2032420 | — | — | 1 | 7.33 |
| CHEMBL2032418 | — | — | 1 | 7.32 |
| CHEMBL2029487 | — | — | 1 | 7.31 |
| CHEMBL2032426 | — | — | 1 | 7.27 |
| CHEMBL2032419 | — | — | 1 | 7.26 |
| CHEMBL2029490 | — | — | 1 | 7.25 |
| CHEMBL2029477 | — | — | 1 | 7.25 |
| CHEMBL2032413 | — | — | 1 | 7.24 |
| CHEMBL2032423 | — | — | 1 | 7.24 |
| CHEMBL2029480 | — | — | 1 | 7.21 |
| CHEMBL2032427 | — | — | 1 | 7.13 |
| CHEMBL2029494 | — | — | 1 | 7.11 |
| CHEMBL2029492 | — | — | 1 | 6.82 |
| CHEMBL2029491 | — | — | 1 | 6.79 |
| CHEMBL2029476 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2032415 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2029489 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2029482 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2029483 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2029481 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2032417 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2032416 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2029484 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2032422 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2032424 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL479527 | TORCETRAPIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2029379 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2032421 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2029486 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2032420 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2032425 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2032418 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2029487 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2032426 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2032419 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2029477 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2029490 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2032413 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2032423 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2029480 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2032427 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2029494 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2029492 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2029491 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL2029476 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL2032412 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL2029493 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL2029496 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL2032414 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL2029488 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL2029485 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL2029495 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL2029479 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2029478 | — | IC50 | > | 50000.0 | nM | - |