Assay Detail
Binding
CHEMBL2033361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha2C adrenergic receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.72 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030634 | — | — | 1 | 6.06 |
| CHEMBL2030626 | — | — | 1 | 5.37 |
| CHEMBL2030623 | — | — | 1 | - |
| CHEMBL2030624 | — | — | 1 | - |
| CHEMBL104700 | — | — | 1 | - |
| CHEMBL2030627 | — | — | 1 | - |
| CHEMBL2030628 | — | — | 1 | - |
| CHEMBL2030629 | — | — | 1 | - |
| CHEMBL2030630 | — | — | 1 | - |
| CHEMBL2030622 | — | — | 1 | - |
| CHEMBL2030632 | — | — | 1 | - |
| CHEMBL2030633 | — | — | 1 | - |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | — | 1 | - |
| CHEMBL2030635 | — | — | 1 | - |
| CHEMBL2030636 | — | — | 1 | - |
| CHEMBL270595 | — | — | 1 | - |
| CHEMBL2030637 | — | — | 1 | - |
| CHEMBL2030631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030634 | — | Ki | = | 862.0 | nM | 6.06 |
| CHEMBL2030626 | — | Ki | = | 4264.0 | nM | 5.37 |
| CHEMBL2030623 | — | Ki | - | — | - | |
| CHEMBL2030624 | — | Ki | - | — | - | |
| CHEMBL104700 | — | Ki | - | — | - | |
| CHEMBL2030627 | — | Ki | - | — | - | |
| CHEMBL2030628 | — | Ki | - | — | - | |
| CHEMBL2030629 | — | Ki | - | — | - | |
| CHEMBL2030630 | — | Ki | - | — | - | |
| CHEMBL2030622 | — | Ki | - | — | - | |
| CHEMBL2030632 | — | Ki | - | — | - | |
| CHEMBL2030633 | — | Ki | - | — | - | |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | Ki | - | — | - | |
| CHEMBL2030635 | — | Ki | - | — | - | |
| CHEMBL2030636 | — | Ki | - | — | - | |
| CHEMBL270595 | — | Ki | - | — | - | |
| CHEMBL2030637 | — | Ki | - | — | - | |
| CHEMBL2030631 | — | Ki | - | — | - |