Assay Detail
Binding
CHEMBL2033577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL2458) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.16 | 7.57 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030550 | — | — | 1 | 7.57 |
| CHEMBL2030543 | — | — | 2 | 6.75 |
| CHEMBL592652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030550 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL2030543 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2030543 | — | Activity | - | — | - | |
| CHEMBL592652 | — | IC50 | >= | 300.0 | nM | - |