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Target Snapshot

CHEMBL2458 Target Snapshot

Peroxisome proliferator-activated receptor delta · SINGLE PROTEIN · Mus musculus

247Compounds
95Assays
0Approved Drugs
188.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P35396. Use UniProt P35396 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35396 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peroxisome proliferator-activated receptor delta as ChEMBL target CHEMBL2458, mapped to UniProt P35396. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peroxisome proliferator-activated receptor delta
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2458
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35396
Peroxisome proliferator-activated receptor delta
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Peroxisome proliferator-activated receptor delta is the right protein anchor across sources, using UniProt P35396 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPeroxisome proliferator-activated receptor delta
UniProt AccessionP35396
Component TypeProtein
Sequence Length440 aa

Peroxisome proliferator-activated receptor delta

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Peroxisome proliferator-activated receptor delta, mapped to UniProt P35396. Sequence length is 440 aa.

Mapped IDP35396
Review namePeroxisome proliferator-activated receptor delta
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC5011.0
EC50177.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1169827 8.64 EC50 2.3 Preclinical
CHEMBL1075894 8.3 EC50 5.0 Preclinical
CHEMBL5267473 8.24 EC50 5.8 Preclinical
CHEMBL5272996 8.21 EC50 6.2 Preclinical
CHEMBL5283926 8.21 EC50 6.1 Preclinical
CHEMBL5289740 8.16 EC50 6.9 Preclinical
CHEMBL5290870 8.16 EC50 6.9 Preclinical
CHEMBL1080699 8.15 EC50 7.0 Preclinical
CHEMBL5277165 8.12 EC50 7.5 Preclinical
CHEMBL4649683 8.1 EC50 7.9 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
11
5.5
8
6.0
11
6.5
32
7.0
31
7.5
14
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

95
Total Assays
67
Tested Compounds
2
Assay Types
Binding — 67 assays, 67 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 36 60 7.0
single protein format 13 7 7.0
tissue-based format 12 0
assay format 6 0
Functional — 28 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 14 31 7.1
cell-based format 14 16 6.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine