Assay Detail
Binding
CHEMBL2033795
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Displacement of 3H-WIN-35428 from DAT in rat striata after 120 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.24 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | 5.43 |
| CHEMBL571548 | — | — | 1 | 5.05 |
| CHEMBL2029645 | — | — | 1 | - |
| CHEMBL2029646 | — | — | 1 | - |
| CHEMBL2029647 | — | — | 1 | - |
| CHEMBL2029648 | — | — | 1 | - |
| CHEMBL2029649 | — | — | 1 | - |
| CHEMBL2029650 | — | — | 1 | - |
| CHEMBL2029651 | — | — | 1 | - |
| CHEMBL2029652 | — | — | 1 | - |
| CHEMBL2029653 | — | — | 1 | - |
| CHEMBL2029351 | — | — | 1 | - |
| CHEMBL2029654 | — | — | 1 | - |
| CHEMBL2029655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1373 | MODAFINIL | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL571548 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2029645 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029646 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029651 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029653 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029351 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029654 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2029655 | — | IC50 | > | 100000.0 | nM | - |