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Assay Detail

CHEMBL2033808

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against X4-tropic HIV1 NL4.3 infected in human MT4 cells assessed as protection from virus-induced cytopathogenicity
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Pharmacophore-based small molecule CXCR4 ligands.
Narumi T, Tanaka T, Hashimoto C, Nomura W, Aikawa H, Sohma A, Itotani K, Kawamata M, Murakami T, Yamamoto N, Tamamura H.
Bioorg Med Chem Lett (2012) 22 : 4169 -4172
PubMed 22579418 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 41 5.87 7.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129 ZIDOVUDINE 4.0 1 7.24
CHEMBL2311028 PLERIXAFOR OCTAHYDROCHLORIDE 1 7.21
CHEMBL436283 1 6.80
CHEMBL2367715 1 6.48
CHEMBL2031844 1 5.13
CHEMBL2031830 1 5.10
CHEMBL2031831 1 5.00
CHEMBL2031822 1 4.96
CHEMBL2031829 1 4.89
CHEMBL2031842 1 -
CHEMBL2031828 1 -
CHEMBL2031818 1 -
CHEMBL2031695 1 -
CHEMBL2031696 1 -
CHEMBL2031697 1 -
CHEMBL2031698 1 -
CHEMBL2031699 1 -
CHEMBL2031700 1 -
CHEMBL2031701 1 -
CHEMBL2031841 1 -
CHEMBL2029373 1 -
CHEMBL2031832 1 -
CHEMBL2031833 1 -
CHEMBL2031834 1 -
CHEMBL2031840 1 -
CHEMBL2031835 1 -
CHEMBL2031836 1 -
CHEMBL2031837 1 -
CHEMBL2031838 1 -
CHEMBL2031839 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129 ZIDOVUDINE EC50 = 58.0 nM 7.24
CHEMBL2311028 PLERIXAFOR OCTAHYDROCHLORIDE EC50 = 62.0 nM 7.21
CHEMBL436283 EC50 = 160.0 nM 6.80
CHEMBL2367715 EC50 = 330.0 nM 6.48
CHEMBL2031844 EC50 = 7400.0 nM 5.13
CHEMBL2031830 EC50 = 8000.0 nM 5.10
CHEMBL2031831 EC50 = 10000.0 nM 5.00
CHEMBL2031822 EC50 = 11000.0 nM 4.96
CHEMBL2031829 EC50 = 13000.0 nM 4.89
CHEMBL2031697 EC50 - -
CHEMBL2031827 EC50 > 20000.0 nM -
CHEMBL2031698 EC50 > 20000.0 nM -
CHEMBL2031699 EC50 - -
CHEMBL2031700 EC50 > 20000.0 nM -
CHEMBL2031701 EC50 > 20000.0 nM -
CHEMBL2031702 EC50 > 20000.0 nM -
CHEMBL2031703 EC50 - -
CHEMBL2031694 EC50 > 20000.0 nM -
CHEMBL2031819 EC50 - -
CHEMBL2031820 EC50 - -
CHEMBL2031821 EC50 > 20000.0 nM -
CHEMBL2031823 EC50 > 11000.0 nM -
CHEMBL2031824 EC50 - -
CHEMBL2031825 EC50 - -
CHEMBL2031826 EC50 > 4000.0 nM -
CHEMBL2031696 EC50 > 20000.0 nM -
CHEMBL2031695 EC50 > 4000.0 nM -
CHEMBL2031818 EC50 > 20000.0 nM -
CHEMBL2031828 EC50 > 20000.0 nM -
CHEMBL2031842 EC50 - -
CHEMBL2031841 EC50 - -
CHEMBL2029373 EC50 > 20000.0 nM -
CHEMBL2031832 EC50 > 20000.0 nM -
CHEMBL2031833 EC50 > 20000.0 nM -
CHEMBL2031834 EC50 - -
CHEMBL2031840 EC50 - -
CHEMBL2031835 EC50 > 20000.0 nM -
CHEMBL2031836 EC50 > 20000.0 nM -
CHEMBL2031837 EC50 > 4000.0 nM -
CHEMBL2031838 EC50 > 4000.0 nM -
CHEMBL2031839 EC50 - -