Assay Detail
Functional
CHEMBL2033944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SU-DHL4 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUD4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.51 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030864 | — | — | 1 | 5.70 |
| CHEMBL2030853 | — | — | 1 | 5.63 |
| CHEMBL2030854 | — | — | 1 | 5.60 |
| CHEMBL2031009 | — | — | 1 | 5.42 |
| CHEMBL2031008 | — | — | 1 | 5.18 |
| CHEMBL2030858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030864 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL2030853 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL2030854 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL2031009 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL2031008 | — | IC50 | = | 6640.0 | nM | 5.18 |
| CHEMBL2030858 | — | IC50 | > | 10000.0 | nM | - |