Assay Detail
Binding
CHEMBL2034202
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Inhibition of trypsin-like activity of proteasome by fluorogenic assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Proteasome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.76 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030283 | — | — | 1 | 6.70 |
| CHEMBL2030453 | — | — | 1 | 6.26 |
| CHEMBL2030462 | — | — | 1 | 6.24 |
| CHEMBL2030461 | — | — | 1 | 6.12 |
| CHEMBL2030464 | — | — | 1 | 5.96 |
| CHEMBL2030465 | — | — | 1 | 5.94 |
| CHEMBL2030458 | — | — | 1 | 5.89 |
| CHEMBL2030459 | — | — | 1 | 5.87 |
| CHEMBL2030463 | — | — | 1 | 5.86 |
| CHEMBL2030460 | — | — | 1 | 5.84 |
| CHEMBL2030454 | — | — | 1 | 5.81 |
| CHEMBL2030455 | — | — | 1 | 5.73 |
| CHEMBL2030281 | — | — | 1 | 5.70 |
| CHEMBL2030457 | — | — | 1 | 5.70 |
| CHEMBL2030275 | — | — | 1 | 5.63 |
| CHEMBL2030276 | — | — | 1 | 5.62 |
| CHEMBL2030456 | — | — | 1 | 5.55 |
| CHEMBL2030278 | — | — | 1 | 5.38 |
| CHEMBL2030274 | — | — | 1 | 5.38 |
| CHEMBL2030284 | — | — | 1 | 5.32 |
| CHEMBL2030277 | — | — | 1 | 5.16 |
| CHEMBL2030279 | — | — | 1 | 5.14 |
| CHEMBL2030282 | — | — | 1 | - |
| CHEMBL2030269 | — | — | 1 | - |
| CHEMBL2030280 | — | — | 1 | - |
| CHEMBL2030273 | — | — | 1 | - |
| CHEMBL2030272 | — | — | 1 | - |
| CHEMBL2030271 | — | — | 1 | - |
| CHEMBL2030270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030283 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2030453 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2030462 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2030461 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2030464 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2030465 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL2030458 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2030459 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2030463 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL2030460 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL2030454 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL2030455 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2030281 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2030457 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2030275 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL2030276 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL2030456 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2030278 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2030274 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL2030284 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2030277 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2030279 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2030282 | — | IC50 | - | — | - | |
| CHEMBL2030269 | — | IC50 | - | — | - | |
| CHEMBL2030280 | — | IC50 | - | — | - | |
| CHEMBL2030273 | — | IC50 | - | — | - | |
| CHEMBL2030272 | — | IC50 | - | — | - | |
| CHEMBL2030271 | — | IC50 | - | — | - | |
| CHEMBL2030270 | — | IC50 | - | — | - |