Compound Detail
CHEMBL2030276
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O=S(=O)(Nc1cc(Sc2ncn[nH]2)c(O)c2ccccc12)c1ccc(-c2ccc(F)cc2)cc1
Basic Information
| ChEMBL ID | CHEMBL2030276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KHLVDETZLFMIDS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
492.6
MW (Da)
5.42
ALogP
6
HBA
3
HBD
108.0
PSA (Ų)
0.27
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.75 | 6.185 | 180.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 180.0 | nM | 6.75 | Inhibition of chymotrypsin-like activity of proteasome by fluorogenic assay | 22220566 |
| Unchecked | IC50 | = | 2370.0 | nM | 5.62 | Inhibition of trypsin-like activity of proteasome by fluorogenic assay | 22220566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22220566 | 10.1021/jm201118h | Unchecked | 3 |
Data from ChEMBL 36 via Core Engine