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Assay Detail

CHEMBL2034616

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Binding
Binding affinity to rabbit muscular GPa by NMR binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
Krimm I, Lancelin JM, Praly JP.
J Med Chem (2012) 55 : 1287 -1295
PubMed 22229710 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 4.98 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2030483 1 5.57
CHEMBL337309 TAXIFOLIN 1 5.32
CHEMBL2030484 1 5.00
CHEMBL277157 1 4.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2030483 IC50 = 2700.0 nM 5.57
CHEMBL337309 TAXIFOLIN IC50 = 4800.0 nM 5.32
CHEMBL2030484 IC50 = 9900.0 nM 5.00
CHEMBL277157 IC50 = 96900.0 nM 4.01