Assay Detail
Functional
CHEMBL2034643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat IP3R1 expressed in chicken DT40 cells assessed as induction of Ca2+ release
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.18 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | — | 1 | 8.55 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 7.64 |
| CHEMBL2030675 | — | — | 1 | 6.97 |
| CHEMBL21825 | — | — | 1 | 5.06 |
| CHEMBL2030678 | — | — | 1 | 4.60 |
| CHEMBL2030676 | — | — | 1 | 4.28 |
| CHEMBL2030677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2030675 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL21825 | — | EC50 | = | 8634.0 | nM | 5.06 |
| CHEMBL2030678 | — | EC50 | = | 25190.0 | nM | 4.60 |
| CHEMBL2030676 | — | EC50 | = | 53030.0 | nM | 4.28 |
| CHEMBL2030677 | — | EC50 | - | — | - |