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Assay Detail

CHEMBL2034646

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2a (CHEMBL251)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of novel adenosine A(2A) receptor antagonists by virtual screening.
Langmead CJ, Andrews SP, Congreve M, Errey JC, Hurrell E, Marshall FH, Mason JS, Richardson CM, Robertson N, Zhukov A, Weir M.
J Med Chem (2012) 55 : 1904 -1909
PubMed 22250781 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.80 8.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1800358 1 8.99
CHEMBL2030690 1 8.80
CHEMBL2030687 1 8.51
CHEMBL2030679 1 8.46
CHEMBL2030689 1 7.91
CHEMBL2030688 1 7.82
CHEMBL2030686 1 7.47
CHEMBL1444408 1 6.15
CHEMBL2030682 1 5.91
CHEMBL1561889 1 5.75
CHEMBL2030684 1 5.70
CHEMBL2030681 1 5.65
CHEMBL1873756 1 5.62
CHEMBL2030685 1 5.53
CHEMBL2030683 1 5.33
CHEMBL2030680 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1800358 Ki = 1.023 nM 8.99
CHEMBL2030690 Ki = 1.585 nM 8.80
CHEMBL2030687 Ki = 3.09 nM 8.51
CHEMBL2030679 Ki = 3.467 nM 8.46
CHEMBL2030689 Ki = 12.3 nM 7.91
CHEMBL2030688 Ki = 15.14 nM 7.82
CHEMBL2030686 Ki = 33.88 nM 7.47
CHEMBL1444408 Ki = 707.95 nM 6.15
CHEMBL2030682 Ki = 1230.27 nM 5.91
CHEMBL1561889 Ki = 1778.28 nM 5.75
CHEMBL2030684 Ki = 1995.26 nM 5.70
CHEMBL2030681 Ki = 2238.72 nM 5.65
CHEMBL1873756 Ki = 2398.83 nM 5.62
CHEMBL2030685 Ki = 2951.21 nM 5.53
CHEMBL2030683 Ki = 4677.35 nM 5.33
CHEMBL2030680 Ki = 7079.46 nM 5.15