Assay Detail
Binding
CHEMBL2034663
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Inhibition of CDC7 in human MDA-MB-231T cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrs
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of XL413, a potent and selective CDC7 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.22 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030393 | — | — | 1 | 7.12 |
| CHEMBL2030400 | — | — | 1 | 7.09 |
| CHEMBL2030402 | — | — | 1 | 6.93 |
| CHEMBL2030404 | — | — | 1 | 6.78 |
| CHEMBL2030405 | — | — | 1 | 6.54 |
| CHEMBL2030389 | — | — | 1 | 6.45 |
| CHEMBL2030390 | — | — | 1 | 6.44 |
| CHEMBL2030399 | — | — | 1 | 6.36 |
| CHEMBL2030401 | — | — | 1 | 6.25 |
| CHEMBL2030387 | — | — | 1 | 6.20 |
| CHEMBL2030398 | — | — | 1 | 6.10 |
| CHEMBL2030397 | — | — | 1 | 6.06 |
| CHEMBL2030403 | — | — | 1 | 5.86 |
| CHEMBL2030396 | — | — | 1 | 5.84 |
| CHEMBL2030376 | — | — | 1 | 5.83 |
| CHEMBL2030386 | — | — | 1 | 5.74 |
| CHEMBL2030395 | — | — | 1 | 5.63 |
| CHEMBL2030392 | — | — | 1 | 5.60 |
| CHEMBL2030394 | — | — | 1 | 5.34 |
| CHEMBL2030391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030393 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2030400 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2030402 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2030404 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL2030405 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL2030389 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL2030390 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL2030399 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2030401 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL2030387 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL2030398 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL2030397 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL2030403 | — | IC50 | = | 1374.0 | nM | 5.86 |
| CHEMBL2030396 | — | IC50 | = | 1434.0 | nM | 5.84 |
| CHEMBL2030376 | — | IC50 | = | 1471.0 | nM | 5.83 |
| CHEMBL2030386 | — | IC50 | = | 1805.0 | nM | 5.74 |
| CHEMBL2030395 | — | IC50 | = | 2356.0 | nM | 5.63 |
| CHEMBL2030392 | — | IC50 | = | 2536.0 | nM | 5.60 |
| CHEMBL2030394 | — | IC50 | = | 4592.0 | nM | 5.34 |
| CHEMBL2030391 | — | IC50 | > | 40000.0 | nM | - |