Assay Detail
Functional
CHEMBL2034721
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Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 18 hrs by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.74 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 9.17 |
| CHEMBL2029384 | VISCOSAMINE | — | 1 | 7.28 |
| CHEMBL2029383 | — | — | 1 | 7.17 |
| CHEMBL2029385 | — | — | 1 | 6.85 |
| CHEMBL2029386 | — | — | 1 | 6.80 |
| CHEMBL2029387 | — | — | 1 | 6.72 |
| CHEMBL2029382 | — | — | 1 | 6.66 |
| CHEMBL2029381 | — | — | 1 | 6.62 |
| CHEMBL2029390 | — | — | 1 | 6.58 |
| CHEMBL2029391 | — | — | 1 | 6.51 |
| CHEMBL2029389 | — | — | 1 | 6.29 |
| CHEMBL2029388 | — | — | 1 | 5.82 |
| CHEMBL2029380 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL2029384 | VISCOSAMINE | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2029383 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2029385 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2029386 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2029387 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2029382 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2029381 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2029390 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2029391 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2029389 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2029388 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2029380 | — | EC50 | = | 7500.0 | nM | 5.12 |