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Compound Detail

CHEMBL2029380

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OCCCCCCCCCCCCCc1cccnc1

Basic Information

ChEMBL ID CHEMBL2029380
Phase Preclinical
Structure Type MOL
InChI Key SAHJYCMEMRPITN-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

277.4
MW (Da)
4.91
ALogP
2
HBA
1
HBD
33.1
PSA (Ų)
0.52
QED
0
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H31NO
MW 277.45
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -0.01

Activity Summary

EC50 5 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
EC50 5.12 5.12 7500.0 1
Trypanosoma brucei brucei
CHEMBL612851
EC50 4.8 4.5767 16000.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24900279 10.1021/ml200160k Trypanosoma brucei brucei 3
24900279 10.1021/ml200160k Leishmania major 1
24900279 10.1021/ml200160k Leishmania mexicana 1
24900279 10.1021/ml200160k Plasmodium falciparum 1
24900279 10.1021/ml200160k HEK-293T 1

Data from ChEMBL 36 via Core Engine