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Assay Detail

CHEMBL2033388

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 (BS221) after 72 hrs by alamar blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.
Rodenko B, Al-Salabi MI, Teka IA, Ho W, El-Sabbagh N, Ali JA, Ibrahim HM, Wanner MJ, Koomen GJ, de Koning HP.
ACS Med Chem Lett (2011) 2 : 901 -906
PubMed 24900279 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 6.96 9.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL477683 PHENYLARSINE OXIDE 1 9.18
CHEMBL55 PENTAMIDINE 4.0 1 8.85
CHEMBL3215666 1 8.41
CHEMBL2029391 1 7.85
CHEMBL2029381 1 7.31
CHEMBL2029390 1 7.07
CHEMBL2029389 1 6.80
CHEMBL2029382 1 6.72
CHEMBL2029383 1 6.66
CHEMBL124025 DIMINAZEN ACETURATE 1 6.58
CHEMBL2029386 1 6.51
CHEMBL2029385 1 6.40
CHEMBL2029384 VISCOSAMINE 1 6.39
CHEMBL2029387 1 6.25
CHEMBL2029388 1 5.64
CHEMBL2029380 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL477683 PHENYLARSINE OXIDE EC50 = 0.66 nM 9.18
CHEMBL55 PENTAMIDINE EC50 = 1.4 nM 8.85
CHEMBL3215666 EC50 = 3.9 nM 8.41
CHEMBL2029391 EC50 = 14.0 nM 7.85
CHEMBL2029381 EC50 = 49.0 nM 7.31
CHEMBL2029390 EC50 = 86.0 nM 7.07
CHEMBL2029389 EC50 = 160.0 nM 6.80
CHEMBL2029382 EC50 = 190.0 nM 6.72
CHEMBL2029383 EC50 = 220.0 nM 6.66
CHEMBL124025 DIMINAZEN ACETURATE EC50 = 260.0 nM 6.58
CHEMBL2029386 EC50 = 310.0 nM 6.51
CHEMBL2029385 EC50 = 400.0 nM 6.40
CHEMBL2029384 VISCOSAMINE EC50 = 410.0 nM 6.39
CHEMBL2029387 EC50 = 560.0 nM 6.25
CHEMBL2029388 EC50 = 2300.0 nM 5.64
CHEMBL2029380 EC50 = 16000.0 nM 4.80