Compound Detail
CHEMBL3215666
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Basic Information
| ChEMBL ID | CHEMBL3215666 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMZUMAJTJUZEKQ-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1650564 |
| Active Moiety | CHEMBL1650564 |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
428.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 8.41 | 7.7333 | 3.9 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 3.9 | nM | 8.41 | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei ... | 24900279 |
| Trypanosoma brucei brucei | EC50 | = | 7.8 | nM | 8.11 | Antitrypanosomal activity against TbAt1-deficient bloodstraem form of Trypanosom... | 24900279 |
| Trypanosoma brucei brucei | EC50 | = | 210.0 | nM | 6.68 | Antitrypanosomal activity against TbAt1-deficient bloodstraem form Trypanosoma b... | 24900279 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900279 | 10.1021/ml200160k | Trypanosoma brucei brucei | 3 |
| 29567458 | 10.1016/j.ejmech.2018.02.087 | Trypanosoma brucei brucei | 1 |
| 29567458 | 10.1016/j.ejmech.2018.02.087 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine