Assay Detail
Binding
CHEMBL2037806
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Displacement of [3H]8-OH-DPAT from human 5HT1A receptor by liquid scintillation counting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.52 |
| CHEMBL2037530 | — | — | 1 | 8.44 |
| CHEMBL2037529 | — | — | 1 | 8.44 |
| CHEMBL2037522 | — | — | 1 | 8.29 |
| CHEMBL2037521 | — | — | 1 | 8.18 |
| CHEMBL2037531 | — | — | 1 | 8.14 |
| CHEMBL2037528 | — | — | 1 | 7.55 |
| CHEMBL2037519 | — | — | 1 | 7.20 |
| CHEMBL2037518 | — | — | 1 | 7.07 |
| CHEMBL2037431 | — | — | 1 | 7.04 |
| CHEMBL2037526 | — | — | 1 | 6.99 |
| CHEMBL2037523 | — | — | 1 | 6.96 |
| CHEMBL2037527 | — | — | 1 | 6.67 |
| CHEMBL1946255 | — | — | 1 | 6.67 |
| CHEMBL2037520 | — | — | 1 | 6.60 |
| CHEMBL1946254 | — | — | 1 | 6.58 |
| CHEMBL2037430 | — | — | 1 | 6.51 |
| CHEMBL2037525 | — | — | 1 | 6.46 |
| CHEMBL1946257 | — | — | 1 | 6.30 |
| CHEMBL2037432 | — | — | 1 | 6.11 |
| CHEMBL1946258 | — | — | 1 | - |
| CHEMBL2037524 | — | — | 1 | - |
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2037530 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL2037529 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL2037522 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2037521 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL2037531 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL2037528 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL2037519 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL2037518 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2037431 | — | Ki | = | 90.5 | nM | 7.04 |
| CHEMBL2037526 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL2037523 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL2037527 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL1946255 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL2037520 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL1946254 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL2037430 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL2037525 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1946257 | — | Ki | = | 495.0 | nM | 6.30 |
| CHEMBL2037432 | — | Ki | = | 771.0 | nM | 6.11 |
| CHEMBL1946258 | — | Ki | - | — | - | |
| CHEMBL2037524 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | Ki | - | — | - |