Assay Detail
Functional
CHEMBL2038367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 BaL infected in HeLa P4/R5 cells assessed as reduction of viral infection incubated for 2 hrs followed by incubated in drug-free medium for 46 hrs by single round infection beta-galactosidase reporter gene assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.36 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035201 | — | — | 1 | 7.00 |
| CHEMBL2035200 | — | — | 1 | 6.52 |
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 6.40 |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 6.10 |
| CHEMBL2035198 | — | — | 1 | 5.85 |
| CHEMBL2035194 | — | — | 1 | 5.57 |
| CHEMBL2035192 | — | — | 1 | 5.44 |
| CHEMBL2035196 | — | — | 1 | 5.19 |
| CHEMBL2035190 | — | — | 1 | 5.16 |
| CHEMBL2035189 | — | — | 1 | 5.16 |
| CHEMBL2035199 | — | — | 1 | 5.11 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 4.95 |
| CHEMBL2035195 | — | — | 1 | 4.91 |
| CHEMBL2035193 | — | — | 1 | 4.88 |
| CHEMBL2035197 | — | — | 1 | 4.87 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.85 |
| CHEMBL2035188 | — | — | 1 | 4.54 |
| CHEMBL2035191 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035201 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2035200 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL105318 | ALOVUDINE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL885 | EMTRICITABINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2035198 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2035194 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2035192 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2035196 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2035190 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2035189 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2035199 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL2035195 | — | EC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2035193 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL2035197 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL2035188 | — | EC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL2035191 | — | EC50 | = | 86400.0 | nM | 4.06 |