Assay Detail
Functional
CHEMBL2038370
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Antiviral activity against wild type HIV1 clade C 98USMSC5016 clinical isolate infected in PHA-P-stimulated human PBMC assessed as reverse transcriptase activity incubated for 6 hrs followed by incubated in drug-free medium for 6 days by multiround infection assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.18 | 8.71 |
| IC90 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 2 | 8.71 |
| CHEMBL105318 | ALOVUDINE | 2.0 | 2 | 8.70 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 2 | 7.66 |
| CHEMBL2035198 | — | — | 2 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL105318 | ALOVUDINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL2035198 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL141 | LAMIVUDINE | IC90 | = | 305.6 | nM | - |
| CHEMBL105318 | ALOVUDINE | IC90 | = | 12.3 | nM | - |
| CHEMBL129 | ZIDOVUDINE | IC90 | = | 34.2 | nM | - |
| CHEMBL2035198 | — | IC90 | = | 84.5 | nM | - |